Production of rubusoside from stevioside by using a thermostable lactase from Thermus thermophilus and solubility enhancement of liquiritin and teniposide.

@article{Nguyen2014ProductionOR,
  title={Production of rubusoside from stevioside by using a thermostable lactase from Thermus thermophilus and solubility enhancement of liquiritin and teniposide.},
  author={Thi Thanh Hanh Nguyen and Seung-Jin Jung and Hee-kyoung Kang and Youngmin Kim and Young-Hwan Moon and Misook Kim and Doman Kim},
  journal={Enzyme and microbial technology},
  year={2014},
  volume={64-65},
  pages={38-43}
}
Solubility is an important factor for achieving the desired plasma level of drug for pharmacological response. About 40% of drugs are not soluble in water in practice and therefore are slowly absorbed, which results in insufficient and uneven bioavailability and GI toxicity. Rubusoside (Ru) is a sweetener component in herbal tea and was discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds, including anticancer compounds. In this study, thirty… CONTINUE READING