Production of rosmarinic acid from perfusion culture ofAnchusa officinalis in a membrane-aerated bioreactor

@article{Su2005ProductionOR,
  title={Production of rosmarinic acid from perfusion culture ofAnchusa officinalis in a membrane-aerated bioreactor},
  author={Wei Wen Su and Arthur E. Humphrey},
  journal={Biotechnology Letters},
  year={2005},
  volume={13},
  pages={889-892}
}
In this study, a perfusion fermentation ofAnchusa officinalis was carried out in a stirred tank bioreactor integrated with an internal cross-flow filter. Bubble-free aeration via microporous membrane fibers was used to provide oxygen. A two-stage culture was successfully conducted in this reactor without filter fouling. In a 17 day fermentation, a cell density of 26 g dw/I and a rosmarinic acid productivity of 94 mg/l day were achieved. This productivity is three times that obtained in a batch… CONTINUE READING

References

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membrane aerated bioreactor

  • W. W. Bethlehem Su, H. S. Caram, A. E. Humphrey
  • Ph.D. Thesis,
  • 1991

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