Production of resistant HIV mutants during antiretroviral therapy.

@article{Ribeiro2000ProductionOR,
  title={Production of resistant HIV mutants during antiretroviral therapy.},
  author={Ruy M. Ribeiro and Sebastian Bonhoeffer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 14},
  pages={
          7681-6
        }
}
HIV drug therapy often fails because of the appearance of multidrug-resistant virus. There are two possible scenarios for the outgrowth of multidrug-resistant virus in response to therapy. Resistant virus may preexist at low frequencies in drug-naive patients and is rapidly selected in the presence of drugs. Alternatively, resistant virus is absent at the start of therapy but is generated by residual viral replication during therapy. Currently available experimental methods are generally too… CONTINUE READING
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