Production of resistant HIV mutants during antiretroviral therapy.

  title={Production of resistant HIV mutants during antiretroviral therapy.},
  author={Ruy M. Ribeiro and Sebastian Bonhoeffer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 14},
HIV drug therapy often fails because of the appearance of multidrug-resistant virus. There are two possible scenarios for the outgrowth of multidrug-resistant virus in response to therapy. Resistant virus may preexist at low frequencies in drug-naive patients and is rapidly selected in the presence of drugs. Alternatively, resistant virus is absent at the start of therapy but is generated by residual viral replication during therapy. Currently available experimental methods are generally too… CONTINUE READING
Highly Cited
This paper has 132 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 92 citations

133 Citations

Citations per Year
Semantic Scholar estimates that this publication has 133 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-2 of 2 references

Infectious Dis. Hum

  • R. M. Anderson, R. M. May
  • 1991

Tables of Integrals, Series, and Products, Corrected and Enlarged (Academic

  • I. S. Gradsteyn, I. M. Ryzhik
  • San Diego),
  • 1980