Production of recombinant protein therapeutics in cultivated mammalian cells

@article{Wurm2004ProductionOR,
  title={Production of recombinant protein therapeutics in cultivated mammalian cells},
  author={Florian Wurm},
  journal={Nature Biotechnology},
  year={2004},
  volume={22},
  pages={1393-1398}
}
  • F. Wurm
  • Published 1 November 2004
  • Biology, Engineering
  • Nature Biotechnology
Cultivated mammalian cells have become the dominant system for the production of recombinant proteins for clinical applications because of their capacity for proper protein folding, assembly and post-translational modification. Thus, the quality and efficacy of a protein can be superior when expressed in mammalian cells versus other hosts such as bacteria, plants and yeast. Recently, the productivity of mammalian cells cultivated in bioreactors has reached the gram per liter range in a number… 
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Recent systems-level studies that utilize genome-scale analytical tools to analyse the functional basis for key production process characteristics such as high cell-specific productivity, correct product processing and rapid cell proliferation in the in vitro environment are summarized.
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