Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity.

@article{Friry2002ProductionOR,
  title={Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity.},
  author={Claire Friry and Sylvain F. Feliciangeli and F. Richard and P. Kitabgi and C. Rov{\`e}re},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={290 4},
  pages={
          1161-8
        }
}
Proneurotensin/neuromedin N (pro-NT/NN) is the common precursor of two biologically active related peptides, neuromedin N (NN) and neurotensin (NT). It undergoes a tissue-specific processing leading to the formation in some tissues and cancer cell lines of large peptides ending with the NT (large NT) or NN (large NN) sequence. In this study, we prepared and purified high amounts of recombinant large NT and large NN using the Drosophila S2 cell expression system. The binding and pharmacological… Expand
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