Production of recombinant albumin by a herd of cloned transgenic cattle

  title={Production of recombinant albumin by a herd of cloned transgenic cattle},
  author={Yann Echelard and Jennifer L. Williams and Margaret M. Destrempes and Julie A. Koster and Susan A. Overton and Daniel P. Pollock and Karen T. Rapiejko and Esmail Behboodi and Nicholas C. Masiello and William G. Gavin and Jerry Pommer and Scott M. Van Patten and David C. Faber and Jose Bernardo Cibelli and Harry M. Meade},
  journal={Transgenic Research},
Purified plasma derived human albumin has been available as a therapeutic product since World War II. However, cost effective recombinant production of albumin has been challenging due to the amount needed and the complex folding pattern of the protein. In an effort to provide an abundant source of recombinant albumin, a herd of transgenic cows expressing high levels of rhA in their milk was generated. Expression cassettes efficiently targeting the secretion of human albumin to the lactating… CONTINUE READING


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  • GM Church, W Gilbert
  • 1984
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