Production of recombinant VP1-derived virus-like particles from novel human polyomaviruses in yeast

@inproceedings{Norkiene2015ProductionOR,
  title={Production of recombinant VP1-derived virus-like particles from novel human polyomaviruses in yeast},
  author={Milda Norkiene and Jomante Stonyte and Danguole Ziogiene and Egle Mazeike and Kestutis Sasnauskas and Alma Gedvilaite},
  booktitle={BMC biotechnology},
  year={2015}
}
BACKGROUND Eleven new human polyomaviruses (HPyVs) have been identified in the last decade. Serological studies show that these novel HPyVs sub-clinically infect humans at an early age. The routes of infection, entry pathways, and cell tropism of new HPyVs remain unknown. VP1 proteins of polyomaviruses can assembly into virus-like particles (VLPs). As cell culturing systems for HPyV are currently not available, VP1-derived VLPs may be useful tools in basic research and biotechnological… CONTINUE READING
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