Production of reactive oxygen species and release of L-glutamate during superoxide anion-induced cell death of cerebellar granule neurons.

@article{Satoh1998ProductionOR,
  title={Production of reactive oxygen species and release of L-glutamate during superoxide anion-induced cell death of cerebellar granule neurons.},
  author={Takeshi Satoh and Tadahiro Numakawa and Yasuhiro Abiru and Takanori Yamagata and Yasuyuki Ishikawa and Yasushi Enokido and Hiroshi Hatanaka},
  journal={Journal of neurochemistry},
  year={1998},
  volume={70 1},
  pages={316-24}
}
Enhanced production of superoxide anion (O2-) is considered to play a pivotal role in the pathogenesis of CNS neurons. Here, we report that O2- generated by xanthine (XA) + xanthine oxidase (XO) triggered cell death associated with nuclear condensation and DNA fragmentation in cerebellar granule neuron. XA + XO induced significant increases in amounts of intracellular reactive oxygen species (ROS) before initiating loss of cell viability, as determined by measurement of 6-carboxy-2',7… CONTINUE READING
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