Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors alpha and beta.

@article{Brown2010ProductionOP,
  title={Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors alpha and beta.},
  author={Candice M Brown and Tara A Mulcahey and Nicole C Filipek and Phyllis M. Wise},
  journal={Endocrinology},
  year={2010},
  volume={151 10},
  pages={
          4916-25
        }
}
Neuroinflammation is a common feature of many neurological disorders, and it is often accompanied by the release of proinflammatory cytokines and chemokines. Estradiol-17β (E2) exhibits antiinflammatory properties, including the suppression of proinflammatory cytokines, in the central nervous system. However, the mechanisms employed by E2 and the role(s) of estrogen receptors (ERs) ERα and ERβ are unclear. To investigate these mechanisms, we employed an in vivo lipopolysaccharide (LPS) model of… CONTINUE READING
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