Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells

@article{DAmour2006ProductionOP,
  title={Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells},
  author={Kevin A. D'Amour and Anne G Bang and Susan Eliazer and Olivia G. Kelly and Alan D. Agulnick and Nora G. Smart and M Allison Moorman and Evert Kroon and Melissa K. Carpenter and Emmanuel E. Baetge},
  journal={Nature Biotechnology},
  year={2006},
  volume={24},
  pages={1392-1401}
}
Of paramount importance for the development of cell therapies to treat diabetes is the production of sufficient numbers of pancreatic endocrine cells that function similarly to primary islets. We have developed a differentiation process that converts human embryonic stem (hES) cells to endocrine cells capable of synthesizing the pancreatic hormones insulin, glucagon, somatostatin, pancreatic polypeptide and ghrelin. This process mimics in vivo pancreatic organogenesis by directing cells through… CONTINUE READING
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