Production of nitric oxide during graft rejection is regulated by the Th1/Th2 balance, the arginase activity, and L-arginine metabolism.

@article{Holan2006ProductionON,
  title={Production of nitric oxide during graft rejection is regulated by the Th1/Th2 balance, the arginase activity, and L-arginine metabolism.},
  author={Vladimir Holan and Jana Pindj{\'a}kov{\'a} and Magdalena Krulov{\'a} and Ale{\vs} Neuwirth and Jan Fric and Alena Zaj{\'i}cov{\'a}},
  journal={Transplantation},
  year={2006},
  volume={81 12},
  pages={
          1708-15
        }
}
BACKGROUND Production of nitric oxide (NO) by graft infiltrating macrophages has been proposed as an important effector mechanism of allograft rejection. Although high levels of NO are generated during allograft rejection, undetectable or only limited amounts of NO were found in rejected skin xenografts. METHODS BALB/c mice were grafted with skin transplants from syngeneic, allogeneic or xenogeneic (rat) donors. The production of NO, cytokines and arginase in the grafts was determined by… CONTINUE READING
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