Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

  title={Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells},
  author={Alessandro D'Andrea and M Rengaraju and Nicholas M. Valiante and Jihed Chehimi and Marek Kubin and Marco Aste and Susan Chan and Michiko Kobayashi and Deborah Young and Elliott Nickbarg},
  journal={The Journal of Experimental Medicine},
  pages={1387 - 1398}
Natural killer cell stimulatory factor (NKSF), or interleukin 12 (IL-12), is a 70-kD heterodimeric cytokine composed of two covalently linked chains, p40 and p35. NKSF/IL-12 has multiple effects on T and NK cells and was originally identified and purified from the supernatant fluid of Epstein-Barr virus (EBV)-transformed human B lymphoblastoid cell lines. We have produced a panel of monoclonal antibodies against both chains of NKSF/IL-12. Some of these antibodies have neutralizing activity, and… CONTINUE READING
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