Production of mutagenic metabolites by Metarhizium anisopliae.

  title={Production of mutagenic metabolites by Metarhizium anisopliae.},
  author={Stuart B Krasnoff and Christopher H. Sommers and Yong-Sun Moon and Bruno Giuliano Garisto Donzelli and John D. Vandenberg and Alice C. L. Churchill and Donna Marie Gibson},
  journal={Journal of agricultural and food chemistry},
  volume={54 19},
NG-391 (1) and NG-393 (2), previously reported from undescribed Fusarium species as nerve-cell growth stimulants, were identified from fermentation extracts of the entomopathogenic fungus Metarhizium anisopliae. These compounds are 7-desmethyl analogues of fusarin C and (8Z)-fusarin C, mutagenic toxins from Fusarium species that contaminate corn. A mutant strain of M. anisopliae (KOB1-3) overproduces 1 and 2 by ca. 10-fold relative to the wild-type strain, ARSEF 2575, from which it was derived… CONTINUE READING

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