Production of monoclonal antibodies with a controlled N-glycosylation pattern in seeds of Arabidopsis thaliana.

@article{Loos2011ProductionOM,
  title={Production of monoclonal antibodies with a controlled N-glycosylation pattern in seeds of Arabidopsis thaliana.},
  author={Andreas Loos and Bart Van Droogenbroeck and Stefan Hillmer and Josephine Grass and Renate E Kunert and Jingyuan Cao and David G Robinson and A. G. Depicker and Herta Steinkellner},
  journal={Plant biotechnology journal},
  year={2011},
  volume={9 2},
  pages={179-92}
}
Seed-specific expression is an appealing alternative technology for the production of recombinant proteins in transgenic plants. Whereas attractive yields of recombinant proteins have been achieved by this method, little attention has been paid to the intracellular deposition and the quality of such products. Here, we demonstrate a comparative study of two antiviral monoclonal antibodies (mAbs) (HA78 against Hepatitis A virus; 2G12 against HIV) expressed in seeds of Arabidopsis wild-type (wt… CONTINUE READING
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