Production of monoclonal antibodies for sandwich immunoassay detection of Pacific ciguatoxins.

@article{Tsumuraya2010ProductionOM,
  title={Production of monoclonal antibodies for sandwich immunoassay detection of Pacific ciguatoxins.},
  author={Takeshi Tsumuraya and Ikuo Fujii and Masahiro Hirama},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2010},
  volume={56 5},
  pages={797-803}
}
Ciguatoxins are the major causative toxins of ciguatera seafood poisoning. Limited availability of ciguatoxins has hampered the development of a reliable and specific immunoassay for detecting these toxins in contaminated fish. Monoclonal antibodies (mAbs) specific against both ends of Pacific ciguatoxins CTX3C and 51-hydroxyCTX3C were prepared by immunization of mice with the protein conjugates of rationally designed synthetic haptens in place of the natural toxin. Haptenic groups that possess… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…