Production of menaquinone (vitamin K2)-7 by Bacillus subtilis.

  title={Production of menaquinone (vitamin K2)-7 by Bacillus subtilis.},
  author={Toshiro Sato and Yuki Yamada and Yutaka Ohtani and Nobuo Mitsui and Hisashi Murasawa and Satoshi Araki},
  journal={Journal of bioscience and bioengineering},
  volume={91 1},
Menaquinone-7 (MK-7) is a highly bioactive homologue of vitamin K. We obtained a diphenylamine-resistant mutant strain D200-41 from Bacillus subtilis strain MH-1 which was isolated from fermented soybeans, natto. The mutant strain exhibited decreased production of MK-6. Using strain D200-41, efficient production of MK-7 was achieved. We found that, compared with an agitated and aerated culture, production of MK-7 was increased by static culture. The sporulation of the cells progressed more… CONTINUE READING
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