Production of membrane whorls in rat liver by some inhibitors of protein synthesis.

@article{Hwang1974ProductionOM,
  title={Production of membrane whorls in rat liver by some inhibitors of protein synthesis.},
  author={Kou M. Hwang and Linda C Yang and C K Carrico and R A Schulz and John B. Schenkman and Alan C. Sartorelli},
  journal={The Journal of cell biology},
  year={1974},
  volume={62 1},
  pages={20-31}
}
Inhibitors of protein synthesis capable of differential effects on nascent peptide synthesis on membrane-bound and free polyribosomes were employed to investigate the structure and function of cellular membranes of liver. The formation of membranous whorls in the cytoplasm and distension of nuclear membranes were induced by inhibitors of protein synthesis (i.e., cycloheximide and emetine) which predominantly interfere with nascent peptide synthesis on membrane-bound polyribosomes in situ. Other… CONTINUE READING
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