Production of macrosphelide A by the mycoparasite Coniothyrium minitans.

  title={Production of macrosphelide A by the mycoparasite Coniothyrium minitans.},
  author={Mark McQuilken and Jacqueline Gemmell and Robert A. Hill and John M. Whipps},
  journal={FEMS microbiology letters},
  volume={219 1},
Coniothyrium minitans, a mycoparasite of sclerotia of Sclerotinia sclerotiorum and Sclerotium cepivorum, produced four closely related metabolites inhibitory to fungal growth. The major metabolite, identified as macrosphelide A, had IG(50) values (the concentration of metabolite to inhibit growth by 50%) of 46.6 and 2.9 microgram ml(-1) against S. sclerotiorum and S. cepivorum, respectively. This is the first report of both antifungal activity due to macrosphelide A as well as isolation of… CONTINUE READING

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