Production of lentiviral vectors.

  title={Production of lentiviral vectors.},
  author={Otto-Wilhelm Merten and Matthias Hebben and Chiara Bovolenta},
  journal={Molecular therapy. Methods & clinical development},
Lentiviral vectors (LV) have seen considerably increase in use as gene therapy vectors for the treatment of acquired and inherited diseases. This review presents the state of the art of the production of these vectors with particular emphasis on their large-scale production for clinical purposes. In contrast to oncoretroviral vectors, which are produced using stable producer cell lines, clinical-grade LV are in most of the cases produced by transient transfection of 293 or 293T cells grown in… CONTINUE READING
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