Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells

The human immunodeficiency virus Vif protein overcomes the inhibitory activity of the APOBEC3G cytidine deaminase by prohibiting its packaging into virions. Inhibition of APOBEC3G encapsidation is paralleled by a reduction of its intracellular level presumably caused by the Vif-induced proteasome-dependent degradation of APOBEC3G. In this report we employed… CONTINUE READING
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