Production of infectious hepatitis C virus by well-differentiated, growth-arrested human hepatoma-derived cells.

@article{Sainz2006ProductionOI,
  title={Production of infectious hepatitis C virus by well-differentiated, growth-arrested human hepatoma-derived cells.},
  author={Bruno Sainz and Francis V. Chisari},
  journal={Journal of virology},
  year={2006},
  volume={80 20},
  pages={10253-7}
}
Dimethyl sulfoxide (DMSO) has been shown to induce the differentiation of primary hepatocytes in vitro. When actively dividing poorly differentiated human hepatoma-derived (Huh7) cells were cultured in the presence of 1% DMSO, cells became cytologically differentiated and transitioned into a nondividing state, characterized by the induction of hepatocyte… CONTINUE READING