Production of hydroxyl radicals by copper-containing metallothionein: roles as prooxidant.

@article{Suzuki1996ProductionOH,
  title={Production of hydroxyl radicals by copper-containing metallothionein: roles as prooxidant.},
  author={Kazuo T. Suzuki and Mei Rui and Jun-ichi Ueda and Tomoyuki Ozawa},
  journal={Toxicology and applied pharmacology},
  year={1996},
  volume={141 1},
  pages={
          231-7
        }
}
Production of hydroxyl radicals by copper (Cu)-containing metallothionein (MT) and its relation to zinc (Zn) bound to MT were studied in vitro with reference to the mechanism of the Cu toxicity in the liver of LEC rats. Zn-MT prepared from the liver of Zn-injected rats was reacted with cupric ions at various Cu/Zn ratios, and the concentrations of the two metals bound to MT and in the solution, valence states of Cu in the solution, production of hydroxyl radicals were determined. Cupric ions… CONTINUE READING
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