Production of hydroxyl radical in the hippocampus after CO hypoxia or hypoxic hypoxia in the rat.


Carbon monoxide poisoning produces both immediate and delayed neuronal injury in selective regions of the brain that is not readily explained on the basis of tissue hypoxia. One possibility is that cellular injury during and after CO poisoning is related to the production of reactive oxygen species (ROS) by the brain. In this study, we hypothesized that the… (More)


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