Production of hydroxyl radical by iron(III)-anthraquinone complexes through self-reduction and through reductive activation by the xanthine oxidase/hypoxanthine system.

@article{Malisza1995ProductionOH,
  title={Production of hydroxyl radical by iron(III)-anthraquinone complexes through self-reduction and through reductive activation by the xanthine oxidase/hypoxanthine system.},
  author={Krisztina L. Malisza and Brian B. Hasinoff},
  journal={Archives of biochemistry and biophysics},
  year={1995},
  volume={321 1},
  pages={51-60}
}
The iron(III) complexes of doxorubicin and epirubicin were observed to undergo a self-reduction (autoxidation) reaction in the absence of added reductants under aerobic conditions that resulted in the formation of ferrous anthracycline complexes. These self-reduction reactions resulted in significant hydrogen peroxide-mediated hydroxyl radical formation, as determined by electron paramagnetic resonance spin trapping. In contrast, the iron(III) complexes of daunorubicin, idarubicin, and… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
These self - reduction reactions resulted in significant hydrogen peroxide - mediated hydroxyl radical formation , as determined by electron paramagnetic resonance spin trapping .
These self - reduction reactions resulted in significant hydrogen peroxide - mediated hydroxyl radical formation , as determined by electron paramagnetic resonance spin trapping .
In contrast , the iron(III ) complexes of daunorubicin , idarubicin , and mitoxantrone produced no significant amount of hydroxyl radical formation .
These self - reduction reactions resulted in significant hydrogen peroxide - mediated hydroxyl radical formation , as determined by electron paramagnetic resonance spin trapping .
These self - reduction reactions resulted in significant hydrogen peroxide - mediated hydroxyl radical formation , as determined by electron paramagnetic resonance spin trapping .
These self - reduction reactions resulted in significant hydrogen peroxide - mediated hydroxyl radical formation , as determined by electron paramagnetic resonance spin trapping .
These self - reduction reactions resulted in significant hydrogen peroxide - mediated hydroxyl radical formation , as determined by electron paramagnetic resonance spin trapping .
All of the iron(III)-anthracycline complexes were able to produce hydroxyl radicals at significantly increased rates in the presence of the xanthine oxidase / hypoxanthine superoxide - generating system .
All of the iron(III)-anthracycline complexes were able to produce hydroxyl radicals at significantly increased rates in the presence of the xanthine oxidase / hypoxanthine superoxide - generating system .
AnthracyclinesChemical structure ofDoxorubicin
The iron(III ) complexes of doxorubicin and epirubicin were observed to undergo a self - reduction ( autoxidation ) reaction in the absence of added reductants under aerobic conditions that resulted in the formation of ferrous anthracycline complexes .
These self - reduction reactions resulted in significant hydrogen peroxide - mediated hydroxyl radical formation , as determined by electron paramagnetic resonance spin trapping .
These self - reduction reactions resulted in significant hydrogen peroxide - mediated hydroxyl radical formation , as determined by electron paramagnetic resonance spin trapping .
All Topics