Production of hydroxyl radical by iron(III)-anthraquinone complexes through self-reduction and through reductive activation by the xanthine oxidase/hypoxanthine system.

@article{Malisza1995ProductionOH,
  title={Production of hydroxyl radical by iron(III)-anthraquinone complexes through self-reduction and through reductive activation by the xanthine oxidase/hypoxanthine system.},
  author={Krisztina L. Malisza and Brian B. Hasinoff},
  journal={Archives of biochemistry and biophysics},
  year={1995},
  volume={321 1},
  pages={51-60}
}
The iron(III) complexes of doxorubicin and epirubicin were observed to undergo a self-reduction (autoxidation) reaction in the absence of added reductants under aerobic conditions that resulted in the formation of ferrous anthracycline complexes. These self-reduction reactions resulted in significant hydrogen peroxide-mediated hydroxyl radical formation, as determined by electron paramagnetic resonance spin trapping. In contrast, the iron(III) complexes of daunorubicin, idarubicin, and… CONTINUE READING
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