Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia.

@article{Li1999ProductionOH,
  title={Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia.},
  author={P Andy Li and Guan Jie Liu and Qing Ping He and Robert A. Floyd and Bo K. Siesj{\"o}},
  journal={Free radical biology & medicine},
  year={1999},
  volume={27 9-10},
  pages={1033-40}
}
Preischemic hyperglycemia is known to aggravate brain damage resulting from transient ischemia. In the present study, we explored whether this aggravation is preceded by an enhanced formation of reactive oxygen species (ROS) during the early reperfusion period. To that end, normo- and hyperglycemic rats were subjected to 15 min of forebrain ischemia and allowed recovery periods of 5, 15, and 60 min. Sodium salicylate was injected intraperitoneally in a dose of 100 mg/kg, and tissues were… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
Sodium salicylate was injected intraperitoneally in a dose of 100 mg / kg , and tissues were sampled during recirculation to allow analyses of salicylic acid ( SA ) and its hydroxylation products , 2,3- and 2,5-dihydroxybenzoate ( DHBA ) .
Sodium salicylate was injected intraperitoneally in a dose of 100 mg / kg , and tissues were sampled during recirculation to allow analyses of salicylic acid ( SA ) and its hydroxylation products , 2,3- and 2,5-dihydroxybenzoate ( DHBA ) .
Sodium salicylate was injected intraperitoneally in a dose of 100 mg / kg , and tissues were sampled during recirculation to allow analyses of salicylic acid ( SA ) and its hydroxylation products , 2,3- and 2,5-dihydroxybenzoate ( DHBA ) .
All Topics