Production of human tissue plasminogen activator (tPA) in Cucumis sativus.

  title={Production of human tissue plasminogen activator (tPA) in Cucumis sativus.},
  author={Mishaneh Asgari and Mokhtar Jalali Javaran and Ahmad Moieni and Asad Masoumiasl and Maryam Abdolinasab},
  journal={Preparative biochemistry & biotechnology},
  volume={44 2},
Tissue plasminogen activator (tPA) as a serine protease with 72 kD molecular mass and 527 amino acids plays an important role in the fibrinolytic system and the dissolution of fibrin clots in human body. The collective production of this drug in plants such as cucumber, one of the most important vegetables in the world, could reduce its production costs. In this study, after scrutiny of the appropriate regeneration of cucumber plant (Isfahan variety) on MS medium with naphthalene acetic acid… CONTINUE READING