Production of human mutant biologically active hepatocyte growth factor in Chinese hamster ovary cells.

Abstract

Hepatocyte growth factor (HGF) is a potent multifunctional cytokine that affects proliferation, migration, and morphogenesis of various cells. HGF is secreted as an inactive single-chain precursor protein and activated by the cleavage of serine proteases to form heterodimers. In our current study, the cleavage site of HGF was blocked by replaced Arg 494 of… (More)
DOI: 10.1080/10826068.2016.1275010

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@article{Xu2017ProductionOH, title={Production of human mutant biologically active hepatocyte growth factor in Chinese hamster ovary cells.}, author={Dongsheng Xu and Aini Wan and Lin Peng and Yun Chen and Yang Bo He and Jianfeng Yang and Jian Jin}, journal={Preparative biochemistry & biotechnology}, year={2017}, volume={47 5}, pages={489-495} }