Production of human antibodies to native cytokine receptors using the genetic immunization of KM mice.

Abstract

We have established a protocol for generating antibodies to native G-protein coupled receptors using genetic immunization with a molecular adjuvant, E. coli Gro-EL. Here, we adapted this protocol for use in transchromosome KM mice, which bear a set of human immunoglobulin genes. The immunization of KM mice using expression plasmids containing genes encoding… (More)
DOI: 10.3233/HAB-2009-0205

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@article{Fujimoto2009ProductionOH, title={Production of human antibodies to native cytokine receptors using the genetic immunization of KM mice.}, author={Akira Fujimoto and Shogo Takatsuka and Isao Ishida and Joe Chiba}, journal={Human antibodies}, year={2009}, volume={18 3}, pages={75-80} }