Production of homoplasmic xenomitochondrial mice.

  title={Production of homoplasmic xenomitochondrial mice.},
  author={Matthew McKenzie and Ian A Trounce and Carolyn A. Cassar and Carl A. Pinkert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 6},
The unique features of mtDNA, together with the lack of a wide range of mouse cell mtDNA mutants, have hampered the creation of mtDNA mutant mice. To overcome these barriers mitochondrial defects were created by introducing mitochondria from different mouse species into Mus musculus domesticus (Mm) mtDNA-less (rho(0)) L cells. Introduction of the closely related Mus spretus (Ms) or the more divergent Mus dunni (Md) mitochondria resulted in xenocybrids exhibiting grossly normal respiratory… CONTINUE READING