Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha.

@article{Aloisi1992ProductionOH,
  title={Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha.},
  author={Francesca Aloisi and Alessandra Car{\`e} and Giovanna Borsellino and Pasquale Gallo and Salvatore Rosa and A Bassani and A Cabibbo and Elvira Pelosi and Giulio Levi and Cesare Peschle},
  journal={Journal of immunology},
  year={1992},
  volume={149 7},
  pages={2358-66}
}
Astrocyte-enriched populations were established from human embryonic brain analyzed for their ability to synthesize cytokines potentially relevant for mechanisms of inflammation and immunity in the brain. Unstimulated astrocytes did not secrete significant IL-6, IL-8, macrophage CSF (M-CSF), granulocyte-macrophage CSF (GM-CSF), or granulocyte-CSF (G-CSF), as determined by specific ELISA and/or bioassay. With the exception of M-CSF mRNA, transcripts for the above factors were not detected in… CONTINUE READING
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