Production of granulocyte-macrophage colony-stimulating factor by large granular lymphocytes stimulated with Candida albicans: role in activation of human neutrophil function.

@article{Blanchard1991ProductionOG,
  title={Production of granulocyte-macrophage colony-stimulating factor by large granular lymphocytes stimulated with Candida albicans: role in activation of human neutrophil function.},
  author={Daphn{\'e} Blanchard and M. Beatriz Michelini-Norris and Julie Y. Djeu},
  journal={Blood},
  year={1991},
  volume={77 10},
  pages={2259-65}
}
In the present study, culture supernatants from larger granular lymphocytes (LGL) that were activated with Candida albicans antigens were shown to stimulate the ability of neutrophils to inhibit fungal growth. Identification of the activation factors showed that granulocyte-macrophage colony-stimulating factor (GM-CSF), a hematopoietic growth factor, was involved. Human peripheral blood mononuclear cells were fractionated by Percoll density centrifugation and each subpopulation of cells was… CONTINUE READING
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