Production of granulocyte colony-stimulating factor in vitro by monocytes from preterm and term neonates.

@article{Schibler1993ProductionOG,
  title={Production of granulocyte colony-stimulating factor in vitro by monocytes from preterm and term neonates.},
  author={Kurt R. Schibler and Kenneth W. Liechty and Wain L. White and Robert D. Christensen},
  journal={Blood},
  year={1993},
  volume={82 8},
  pages={2478-84}
}
We postulated that defective generation of granulocyte colony-stimulating factor (G-CSF) by cells of newborn infants might underlie their deficiencies in upregulating neutrophil production and function during bacterial infection. To test this, we isolated monocytes from the blood of preterm neonates, term neonates, and adults and, after stimulation with various concentrations of interleukin-1 alpha (IL-1 alpha) or lipopolysaccharide (LPS), quantified G-CSF concentrations in cell supernatants… CONTINUE READING
18 Extracted Citations
48 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 18 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 48 references

Interleu - kin1 signal transduction : Increased GTP binding and hydrolysis in membranes of murine thymoma line ( EL 4 )

  • ONeill LAJ, TA Bird, Gearing AJH, J Saklatvala
  • J Biol Chem
  • 1990

Similar Papers

Loading similar papers…