Production of gene-targeted sheep by nuclear transfer from cultured somatic cells

@article{McCreath2000ProductionOG,
  title={Production of gene-targeted sheep by nuclear transfer from cultured somatic cells},
  author={K. McCreath and J. Howcroft and K. Campbell and A. Colman and A. Schnieke and A. Kind},
  journal={Nature},
  year={2000},
  volume={405},
  pages={1066-1069}
}
It is over a decade since the first demonstration that mouse embryonic stem cells could be used to transfer a predetermined genetic modification to a whole animal. The extension of this technique to other mammalian species, particularly livestock, might bring numerous biomedical benefits, for example, ablation of xenoreactive transplantation antigens, inactivation of genes responsible for neuropathogenic disease and precise placement of transgenes designed to produce proteins for human therapy… Expand
Genetic modification of sheep by nuclear transfer with gene-targeted somatic cells.
Gene targeting in primary fetal fibroblasts from sheep and pig.
Cell-Mediated Transgenesis in Rabbits: Chimeric and Nuclear Transfer Animals1
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