Production of functional chimaeric mouse/human antibody

@article{Boulianne1984ProductionOF,
  title={Production of functional chimaeric mouse/human antibody},
  author={Gabrielle L. Boulianne and Nobumichi Hozumi and Marc J. Shulman},
  journal={Nature},
  year={1984},
  volume={312},
  pages={643-646}
}
The availability of monoclonal antibodies has revived interest in immunotherapy. The ability to influence an individual's immune state by administering immunoglobulin of the appropriate specificity may provide a powerful approach to disease control and prevention. Compared with immunoglobulin from other species, human immunoglobulin (Ig) might be best for such therapeutic intervention; it might function better with the recipient's effector cells and should itself be less immunogenic. The… 

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