Production of erythroid potentiating factor(s) by a human monocytic cell line.

@article{Ascensao1981ProductionOE,
  title={Production of erythroid potentiating factor(s) by a human monocytic cell line.},
  author={Joao L. Ascensao and Neil E Kay and T Earenfight-Engler and Hillel S U S Koren and Esmail D. Zanjani},
  journal={Blood},
  year={1981},
  volume={57 1},
  pages={170-3}
}
U-937 is a human monocytic cell line that has been to elaborate factors that affect normal human hematopoiesis in vitro. Studies on the effects of these factors demonstrated an erythroid potentiating factor (EPF) and a potent inhibitor of granulocyte-macrophage (CFU-GM) colony growth. The EPF was present in both serum-containing and serum-free U-937 conditioned media, had a dose-dependent effect on erythroid colony formation and was remarkably heart stable. The CFU-GM inhibitory activity was… CONTINUE READING
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