Production of erythroid-potentiating activity by a human T-lymphoblast cell line.

@article{Golde1980ProductionOE,
  title={Production of erythroid-potentiating activity by a human T-lymphoblast cell line.},
  author={David W. Golde and Noelle Bersch and Shirley G. Quan and Aldons J. Lusis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 1},
  pages={593-6}
}
We derived a human T-lymphoblast cell line (Mo) that constitutively elaborates certain lymphokines. The Mo cells produce a colony-stimulating factor necessary for the growth of human granulocyte-monocyte precursors in vitro as well as an erythroid-potentiating activity (EPA) that enhances the proliferation of human erythroid progenitors in vitro. In the presence of serum, the EPA in Mo-conditioned medium stimulated the growth of small and large erythroid colonies almost 2-fold. EPA was also… CONTINUE READING

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