Production of erythrocytes from directly isolated or Delta1 Notch ligand expanded CD34+ hematopoietic progenitor cells: process characterization, monitoring and implications for manufacture.

Abstract

BACKGROUND AIMS Economic ex vivo manufacture of erythrocytes at 10(12) cell doses requires an efficiently controlled bio-process capable of extensive proliferation and high terminal density. High-resolution characterization of the process would identify production strategies for increased efficiency, monitoring and control. METHODS CD34(+) cord blood… (More)
DOI: 10.1016/j.jcyt.2013.04.008

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@article{Glen2013ProductionOE, title={Production of erythrocytes from directly isolated or Delta1 Notch ligand expanded CD34+ hematopoietic progenitor cells: process characterization, monitoring and implications for manufacture.}, author={Katie E. Glen and Victoria L Workman and Forhad Ahmed and Elizabeth Ratcliffe and Adrian J Stacey and Robert James Thomas}, journal={Cytotherapy}, year={2013}, volume={15 9}, pages={1106-17} }