Production of endothelin 1 by cultured bovine retinal endothelial cells and presence of endothelin receptors on associated pericytes.

@article{Takahashi1989ProductionOE,
  title={Production of endothelin 1 by cultured bovine retinal endothelial cells and presence of endothelin receptors on associated pericytes.},
  author={Kazuhiro Takahashi and Roger Audley Brooks and Sandip M Kanse and Mohammad A. Ghatei and EvaM. Kohner and Stephen R. Bloom},
  journal={Diabetes},
  year={1989},
  volume={38 9},
  pages={
          1200-2
        }
}
Endothelinlike immunoreactivity was detected by radioimmunoassay in medium conditioned by cultured endothelial cells obtained from bovine retinal microvessels (9.2 +/- 6.5 pM, n = 4). Sephadex G-25 column chromatography and fast-protein liquid chromatography revealed that most of the endothelinlike immunoreactivity was eluted in an identical position to synthetic endothelin 1. Retinal capillary pericyte-conditioned medium contained 2.9 pM endothelinlike immunoreactivity. In contrast to… CONTINUE READING
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