Production of endometrial matrix metalloproteinases, but not their tissue inhibitors, is modulated by progesterone withdrawal in an in vitro model for menstruation.

@article{Salamonsen1997ProductionOE,
  title={Production of endometrial matrix metalloproteinases, but not their tissue inhibitors, is modulated by progesterone withdrawal in an in vitro model for menstruation.},
  author={Lois A. Salamonsen and Ali. R. Butt and Forrest Hammond and S Hern{\'a}ndez Garc{\'i}a and Jin Zhang},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1997},
  volume={82 5},
  pages={1409-15}
}
Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are implicated in normal menstruation, but the mechanism of their regulation is not yet clear. Human endometrial stromal cell cultures were established to mimic the events of the late luteal phase of the menstrual cycle: after 6 days of culture with estradiol 17beta (10 nmol/L) and progestin (P, 100 nmol/L), half the cells were subjected to P withdrawal, and medium was harvested on day 10. Decidualization of the cells was… CONTINUE READING
37 Citations
34 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Immunolocalization of the matrix metalloproteinases, gelatinase B and stromelysin-1 in human endometrium throughout the menstrual cycle

  • M Jeziorska, LA Salamonsen, DE. Woolley
  • J Reprod Fertil
  • 1996
1 Excerpt

Tissue inhibitors

  • AL Hampton, AR Butt, SC Riley, LA. Salamonsen
  • SALAMONSEN ET AL. JCE & M
  • 1995
2 Excerpts

Similar Papers

Loading similar papers…