Production of endogenous pyrogen.

  title={Production of endogenous pyrogen.},
  author={Charles A Dinarello},
  journal={Federation proceedings},
  volume={38 1},
The production and release of endogenous pyrogen by the host is the first step in the pathogenesis of fever. Endogenous pyrogen is a low-molecular-weight protein released from phagocytic leukocytes in response to several substances of diverse nature. Some of these agents stimulate production of endogenous pyrogen because they are toxic; others act as antigens and interact with either antibody or sensitized lymphocytes in order to induce its production. Some tumors of macrophage origin produce… CONTINUE READING