Production of d-ribose by fermentation

@article{Wulf1997ProductionOD,
  title={Production of d-ribose by fermentation},
  author={Peter De Wulf and Erick J Vandamme},
  journal={Applied Microbiology and Biotechnology},
  year={1997},
  volume={48},
  pages={141-148}
}
The production of d-ribose by fermentation has received much attention lately, possibly because of the use of this pentose to synthesize antiviral and anticancer drugs. This review briefly outlines the methods that have been used to synthesize d-ribose since it was identified in yeast RNA, and focuses in particular on the latest developments in d-ribose fermentation, which have led to d-ribose yields that exceed 90 g/l. Furthermore, the various transketolase-deficient d-ribose-producing mutants… 

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TLDR
This study represents the first example of engineered E. coli for production of D-ribose from glucose and xylose, and demonstrates reengineering of a glucose-xylose co-utilizing mutant co- utilizing mutant LMSE2.

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TLDR
L-ribose and L-arabinose were prepared biochemically from ribitol by oxidation using Acetobacter aceti IFO 3281 and isomerization using L-RI and L -arabinoses isomerase (L-AI), respectively.

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TLDR
Findings indicated the D-ribose production performance was significantly improved compared to that under original conditions.

Fed-batch production of d-ribose from sugar mixtures by transketolase-deficient Bacillus subtilis SPK1

TLDR
Optimized fed-batch fermentation of B. subtilis SPK1, feeding a mixture of 200 g l−1 xylose and 50 g-l-1 glucose after the late-exponential phase reduced the residual xylOSE and glucose concentrations to less than 7.0 g–1d-ribose and gave the best results, which were 2.0- and 1.2-fold higher than the corresponding values in a simple batch fermentation.

Optimization of medium components for D-ribose production by transketolase-deficient Bacillus subtilis NJT-1507

Statistical experimental designs were used to optimize the composition of culture media for the production of D-ribose by Bacillus subtilis. A fractional factorial design 2(5-2) was used to determine

Enhanced d-ribose biosynthesis in batch culture of a transketolase-deficient Bacillus subtilis strain by citrate

TLDR
Investigation of batch culture of a transketolase-deficient strain of Bacillus subtilis EC2 indicated that citrate addition resulted in increased fluxes in the pentose phosphate pathway and TCA cycle, and decreased fluxe in the glycolysis and acetate pathways.

Combined effects of carbon, nitrogen and phosphorus substrates on D‐ribose production via transketolase deficient strain of Bacillus pumilus

TLDR
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