Production of colony-stimulating activity by normal and neoplastic human B lymphocytes.

@article{Pistoia1987ProductionOC,
  title={Production of colony-stimulating activity by normal and neoplastic human B lymphocytes.},
  author={Vito Pistoia and Riccardo Ghio and Silvio Roncella and Federico Cozzolino and Simona Zupo and Matteo Ferrarini},
  journal={Blood},
  year={1987},
  volume={69 5},
  pages={
          1340-7
        }
}
Normal human B cells were purified from peripheral blood or tonsils and tested for their ability to release colony-stimulating activity (CSA) in short-term cultures. The target cells used in the CSA assays were from peripheral blood or bone marrow. Unstimulated B cells produced CSA in amounts similar to those present in the GCT-conditioned medium used as a positive control. The B cell-derived CSA predominantly promoted the growth of colonies that contained macrophages alone or macrophages and… CONTINUE READING

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