Production of colony-stimulating activity by human natural killer cells: analysis of the conditions that influence the release and detection of colony-stimulating activity.

@article{Pistoia1989ProductionOC,
  title={Production of colony-stimulating activity by human natural killer cells: analysis of the conditions that influence the release and detection of colony-stimulating activity.},
  author={Vito Pistoia and Simona Zupo and Anna Corcione and Silvio Roncella and Lina Matera and Riccardo Ghio and Marina Ferrarini},
  journal={Blood},
  year={1989},
  volume={74 1},
  pages={
          156-64
        }
}
Highly purified natural killer (NK) cell suspensions were tested for their capacity to release colony-stimulating activity (CSA) in vitro. NK cell suspensions comprised primarily CD16+ cells and were devoid of CD3+ T cells, CD15+ monocytes, and of B cells. CSA was detected in the NK cell supernatants and sustained the growth of myeloid colonies from both normal peripheral blood and bone marrow. CSA could be in part inhibited by pretreating NK cell culture supernatants with a specific goat anti… CONTINUE READING

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