Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

@article{Dayer1976ProductionOC,
  title={Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.},
  author={Jean-Michel Dayer and Stephen M. Krane and R. Graham G. Russell and Dwight R. Robinson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1976},
  volume={73 3},
  pages={945-9}
}
We have studied cells dispersed with proteolytic enzymes from rheumatoid arthritic synovectomy specimens to determine the cell type(s) responsible for joint destruction. Initially 10-50% of these cells adhered to culture dishes within 24 hr and were of two main types: small, round cells and larger, stellate cells. During 1-4 days of culture, 5-25% had Fc receptors and 25-50% showed brisk phagocytosis. Daily producition, per 10(6) cells of collagenase (EC 3.4.24.3) (after trypsin pretreatment… CONTINUE READING
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