Production of chondroitin in metabolically engineered E. coli.

@article{He2015ProductionOC,
  title={Production of chondroitin in metabolically engineered E. coli.},
  author={Wenqin He and Li Fu and Guoyun Li and J Andrew Jones and Robert J. Linhardt and Mattheos A G Koffas},
  journal={Metabolic engineering},
  year={2015},
  volume={27},
  pages={
          92-100
        }
}
Chondroitin sulfates, widely used in the treatment of arthritis, are glycosaminoglycans extracted from food animal tissues. As part of our ongoing efforts to separate the food chain from the drug chain, we are examining the possibility of using metabolic engineering to produce chondroitin sulfate in Escherichia coli. Chondroitin is a valuable precursor in the synthesis of chondroitin sulfate. This study proposes a safer and more feasible approach to metabolically engineer chondroitin production… CONTINUE READING
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