Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux.

@article{Kruth1994ProductionOC,
  title={Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux.},
  author={Howard S. Kruth and Sonia I Skarlatos and P M Gaynor and W. Gamble},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 39},
  pages={24511-8}
}
Atherosclerotic lesions have a lipid core containing crystals and liposomes enriched in unesterified cholesterol as well as numerous monocyte-macrophages enriched in cholesteryl ester. Sufficient amounts of plasma-derived high density lipoproteins (HDL) may not reach and efficiently remove the cholesterol deposited in lesion macrophages or in the lipid core of lesions. We examined the potential of human monocyte-macrophages to produce nascent HDL and to solubilize cholesterol derived from… CONTINUE READING
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