Production of brefeldin-A

  title={Production of brefeldin-A},
  author={Thomas G. McCloud and Michael P. Burns and Fathy Majadly and Gary M. Muschik and Debi Miller and Karyol Poole and John M Roach and John T. Ross and William B. Lebherz},
  journal={Journal of Industrial Microbiology},
Fermentation conditions are described for the production of the antitumor antibiotic 7-(S)-brefeldin-A (brefeldin-A) in liquid culture byEupenicillium brefeldianum, (B. Dodge) Stolk and Scott, ATCC 58665. An analytical hplc method was developed which allowed rapid quantitation of the compound during fermentation. A kilogram of brefeldin-A was isolated from a fermentation at the 6800-liter scale. 
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Die Konstitution von Brefeldin A
The constitution of Brefeldin A, a mold metabolite from Penicillium brefeldianum DODGE, has been elucidated as 1 by chemical degradation.