Production of biologically active equine interleukin 12 through expression of p35, p40 and single chain IL-12 in mammalian and baculovirus expression systems.

@article{McMonagle2001ProductionOB,
  title={Production of biologically active equine interleukin 12 through expression of p35, p40 and single chain IL-12 in mammalian and baculovirus expression systems.},
  author={Ellen McMonagle and Samantha J Taylor and Hanneke I van Zuilekom and Laurie H Sanders and Nicolette C Scholtes and L J Keanie and Carol A. Hopkins and Niall A Logan and Derek Bain and David John Argyle and David E. Onions and Virgil E. J. C. Schijns and Lesley Nicolson},
  journal={Equine veterinary journal},
  year={2001},
  volume={33 7},
  pages={693-8}
}
Interleukin-12 (IL-12) is a key cytokine in the development of cell-mediated immune responses. Bioactive IL-12 is a heterodimeric cytokine composed of disulphide linked p35 and p40 subunits. The aim of this study was to verify biologically activity of the products expressed from equine interleukin-12 (IL-12) p35 and p40 cDNAs and to establish whether equine IL-12 could be expressed as a p35/p40 fusion polypeptide, as has been reported for IL-12a of several mammalian species. We report… CONTINUE READING

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