Production of antibodies in transgenic plants

  title={Production of antibodies in transgenic plants},
  author={Andrew Hiatt and Robert Caffferkey and Katherine Bowdish},
COMPLEMENTARY DNAs derived from a mouse hybridoma messenger RNA were used to transform tobacco leaf segments followed by regeneration of mature plants. Plants expressing single gamma or kappa immunoglobulin chains were crossed to yield progeny in which both chains were expressed simultaneously. A functional antibody accumulated to 1.3% of total leaf protein in plants expressing full-length cDNAs containing leader sequences. Specific binding of the antigen recognized by these antibodies was… CONTINUE READING
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