Production of an anti-complement exo-polymer produced by Auricularia auricula-judae in submerged culture

  title={Production of an anti-complement exo-polymer produced by Auricularia auricula-judae in submerged culture},
  author={Sang Chul Jeong and Sung-Pill Cho and Byung-Keun Yang and Young-Ah Gu and Jin-Ho Jang and Tae Lin Huh and Chi-Hyun Song},
  journal={Biotechnology Letters},
Exo-polymer (EP) was produced at 1.2 g l−1 in submerged culture of Auricular auricula-judae. Crude EP (AJ-0) has 70% anti-complementary activity (inhibition of total complementary hemolysis 50%; ITCH50). The activating pathway of the complement system occurred through both the classical and alternative pathways, though the major pathway was the classical one. Fractionation of AJ-0 using Sepharose CL-6B gel chromatography gave three major fractions (AJ-Fr-I, II and III) of which the first was… 
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